Oy Vey! My Son Is Gay! is the story of the Hirsch's, a Jewish family living in the North Shore of Long Island, where every Friday night Shirley Hirsch (Lainie Kazan) invites another "perfect" girl for Shabbat dinner in hopes that her son, Nelson (John Lloyd Young), will marry a nice Jewish girl.
When Shirley and Martin (Saul Rubinek) once again set him up on a date, Nelson reveals that he is already seeing someone. Shirley and Martin are thrilled and can't wait to meet the lucky lady.
Nelson finally breaks the news to his parents that he is gay. At first, Shirley and Martin are confused and distraught, but when the reality starts to set in they begin to blame one another for Nelson's sexuality.